Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantation.
Identifieur interne : 001127 ( Main/Exploration ); précédent : 001126; suivant : 001128Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantation.
Auteurs : Alexander Klein [Allemagne] ; Ian Q. WhishawSource :
- Progress in brain research [ 1875-7855 ] ; 2012.
English descriptors
- KwdEn :
- Animals, Cell Transplantation (physiology), Corpus Striatum (cytology), Corpus Striatum (transplantation), Disease Models, Animal, Humans, Huntington Disease (complications), Mice, Motor Skills (physiology), Motor Skills Disorders (etiology), Motor Skills Disorders (surgery), Parkinson Disease (complications), Substantia Nigra (cytology), Substantia Nigra (transplantation).
- MESH :
- complications : Huntington Disease, Parkinson Disease.
- cytology : Corpus Striatum, Substantia Nigra.
- etiology : Motor Skills Disorders.
- physiology : Cell Transplantation, Motor Skills.
- surgery : Motor Skills Disorders.
- transplantation : Corpus Striatum, Substantia Nigra.
- Animals, Disease Models, Animal, Humans, Mice.
Abstract
Neural transplantation holds the promise for restoring behavioral function following brain injury. Substantial evidence indicates that fetal neurons transplanted to the adult brain survive and incorporate into remaining neural tissue and produce positive behavioral effects. A yet-unanswered question is whether the integration of new tissue can restore complex neural circuits that connect the neocortex, basal ganglia, and brainstem, and restore functions that are mediated by these circuits. This chapter describes the skilled reaching task, a task that requires transport of the arm and hand to grasp a food item and withdrawal to place the food item in the mouth for eating. It is a movement that is readily expressed in rodents and is fundamental to both nonhuman primates and humans. Methods for analyzing skilled reaching have been developed for preclinical rodent and mouse models of Parkinson's disease and Huntington's disease that are generalizable to humans with those clinical disorders. It is suggested that the task provides a motor benchmark for assessing the restoration of function produced by neural transplantation.
DOI: 10.1016/B978-0-444-59575-1.00013-2
PubMed: 23195424
Affiliations:
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Le document en format XML
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Whishaw</name></author></analytic><series><title level="j">Progress in brain research</title><idno type="eISSN">1875-7855</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Transplantation (physiology)</term><term>Corpus Striatum (cytology)</term><term>Corpus Striatum (transplantation)</term><term>Disease Models, Animal</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Mice</term><term>Motor Skills (physiology)</term><term>Motor Skills Disorders (etiology)</term><term>Motor Skills Disorders (surgery)</term><term>Parkinson Disease (complications)</term><term>Substantia Nigra (cytology)</term><term>Substantia Nigra (transplantation)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Motor Skills Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Transplantation</term><term>Motor Skills</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Motor Skills Disorders</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neural transplantation holds the promise for restoring behavioral function following brain injury. Substantial evidence indicates that fetal neurons transplanted to the adult brain survive and incorporate into remaining neural tissue and produce positive behavioral effects. A yet-unanswered question is whether the integration of new tissue can restore complex neural circuits that connect the neocortex, basal ganglia, and brainstem, and restore functions that are mediated by these circuits. This chapter describes the skilled reaching task, a task that requires transport of the arm and hand to grasp a food item and withdrawal to place the food item in the mouth for eating. It is a movement that is readily expressed in rodents and is fundamental to both nonhuman primates and humans. Methods for analyzing skilled reaching have been developed for preclinical rodent and mouse models of Parkinson's disease and Huntington's disease that are generalizable to humans with those clinical disorders. It is suggested that the task provides a motor benchmark for assessing the restoration of function produced by neural transplantation.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Hanovre</li></settlement></list><tree><noCountry><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q" last="Whishaw">Ian Q. Whishaw</name></noCountry><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Klein, Alexander" sort="Klein, Alexander" uniqKey="Klein A" first="Alexander" last="Klein">Alexander Klein</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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